Serine protease HTRA1

E2457Mo

Sandwich

48T,96T

14.75ng/L

30-9000ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves (PubMed:18551132) or not (PubMed:14973287). By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

51,214

56213

AI429470;High-temperature requirement A serine peptidase 1;Htr;HTRA;HTRA1;L5;L56;Pr;RS;RSPP11;Serine protease 11;Serine protease HTRA1

Htra1

Others

HTRA1